EXTH-65. AS1411 ENHANCES CYTOTOXICITY OF SapC-DOPS VIA SURFACE PHOSPHATIDYLSERINE ELEVATION IN GLIOBLASTOMA
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چکیده
منابع مشابه
Targeting and Cytotoxicity of SapC-DOPS Nanovesicles in Pancreatic Cancer
Only a small number of promising drugs target pancreatic cancer, which is the fourth leading cause of cancer deaths with a 5-year survival of less than 5%. Our goal is to develop a new biotherapeutic agent in which a lysosomal protein (saposin C, SapC) and a phospholipid (dioleoylphosphatidylserine, DOPS) are assembled into nanovesicles (SapC-DOPS) for treating pancreatic cancer. A distinguishi...
متن کاملCytotoxicity and Selectivity in Skin Cancer by SapC-DOPS Nanovesicles.
Squamous cell carcinoma (SCC) and melanoma are malignant human cancers of the skin with an annual mortality that exceed 10,000 cases every year in the USA alone. In this study, the lysosomal protein saposin C (SapC) and the phospholipid dioloylphosphatidylserine (DOPS) were assembled into cancer-selective nanovesicles (SapC-DOPS) and successfully tested using several in vitro and in vivo skin c...
متن کاملCorrection: Targeting and Cytotoxicity of SapC-DOPS Nanovesicles in Pancreatic Cancer
Fig. 1 is incorrect. The Western blot in Fig. 1E displays the incorrect cell line. The authors have provided a corrected version here. open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
متن کاملPhosphatidylserine-selective targeting and anticancer effects of SapC-DOPS nanovesicles on brain tumors
Brain tumors, either primary (e.g., glioblastoma multiforme) or secondary (metastatic), remain among the most intractable and fatal of all cancers. We have shown that nanovesicles consisting of Saposin C (SapC) and dioleylphosphatidylserine (DOPS) are able to effectively target and kill cancer cells both in vitro and in vivo. These actions are a consequence of the affinity of SapC-DOPS for phos...
متن کاملSapC-DOPS-induced lysosomal cell death synergizes with TMZ in glioblastoma
SapC-DOPS is a novel nanotherapeutic that has been shown to target and induce cell death in a variety of cancers, including glioblastoma (GBM). GBM is a primary brain tumor known to frequently demonstrate resistance to apoptosis-inducing therapeutics. Here we explore the mode of action for SapC-DOPS in GBM, a treatment being developed by Bexion Pharmaceuticals for clinical testing in patients. ...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2017
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/nox168.357